Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma
Sasha Bernatsky
(1)
,
Héctor a Velásquez García
,
John J Spinelli
,
Patrick Gaffney
(2)
,
Karin E Smedby
,
Rosalind Ramsey-Goldman
,
Sophia S Wang
,
Hans-Olov Adami
,
Demetrius Albanes
,
Emanuele Angelucci
,
Stephen M Ansell
,
Yan W Asmann
,
Nikolaus Becker
,
Yolanda Benavente
,
Sonja I Berndt
,
Kimberly A Bertrand
,
Brenda M Birmann
,
Heiner Boeing
,
Paolo Boffetta
,
Paige M Bracci
,
Paul Brennan
,
Angela R Brooks-Wilson
,
James R Cerhan
,
Stephen J Chanock
,
Jacqueline Clavel
,
Lucia Conde
,
Karen H Cotenbader
,
David G Cox
,
Wendy Cozen
,
Simon Crouch
,
Anneclaire J De Roos
,
Silvia De Sanjose
,
Simonetta Di Lollo
,
W Ryan Diver
,
Ahmet Dogan
,
Lenka Foretova
,
Hervé Ghesquières
,
Graham G Giles
,
Bengt Glimelius
,
Thomas M Habermann
,
Corinne Haioun
,
Patricia Hartge
,
Henrik Hjalgrim
,
Theodore R Holford
,
Elizabeth A Holly
,
Rebecca D Jackson
,
Rudolph Kaaks
,
Eleanor Kane
,
Rachel S Kelly
,
Robert J Klein
,
Peter Kraft
,
Anne Kricker
,
Qing Lan
,
Charles Lawrence
,
Mark Liebow
,
Tracy Lightfoot
,
Brian K Link
,
Marc Maynadie
(3, 4, 5, 6)
,
James Mckay
,
Mads Melbye
,
Thierry J Molina
,
Alain Monnereau
,
Lindsay M Morton
,
Alexandra Nieters
,
Kari E North
,
Anne J Novak
,
Kenneth Offit
,
Mark P Purdue
,
Marco Rais
,
Jacques Riby
,
Eve Roman
,
Nathaniel Rothman
,
Gilles Salles
,
Gianluca Severi
,
Richard K Severson
,
Christine F Skibola
,
Susan L Slager
,
Alex Smith
,
Martyn T Smith
,
Melissa C Southey
,
Anthony Staines
,
Lauren R Teras
,
Carrie A Thompson
,
Hervé Tilly
,
Lesley F Tinker
,
Anne Tjonneland
,
Jenny Turner
,
Claire M Vajdic
,
Roel C H Vermeulen
,
Joseph Vijai
,
Paolo Vineis
,
Jarmo Virtamo
,
Zhaoming Wang
,
Stephanie Weinstein
,
Thomas E Witzig
,
Andrew Zelenetz
,
Anne Zeleniuch-Jacquotte
,
Yawei Zhang
,
Tongzhang Zheng
,
Mariagrazia Zucca And
(7)
,
Ann E Clarke
(7)
Héctor a Velásquez García
- Function : Author
John J Spinelli
- Function : Author
Karin E Smedby
- Function : Author
Rosalind Ramsey-Goldman
- Function : Author
Sophia S Wang
- Function : Author
Hans-Olov Adami
- Function : Author
Demetrius Albanes
- Function : Author
Emanuele Angelucci
- Function : Author
- PersonId : 786380
- ORCID : 0000-0002-6512-6080
Stephen M Ansell
- Function : Author
Yan W Asmann
- Function : Author
Nikolaus Becker
- Function : Author
Yolanda Benavente
- Function : Author
Sonja I Berndt
- Function : Author
Kimberly A Bertrand
- Function : Author
Brenda M Birmann
- Function : Author
Heiner Boeing
- Function : Author
Paolo Boffetta
- Function : Author
Paige M Bracci
- Function : Author
Paul Brennan
- Function : Author
Angela R Brooks-Wilson
- Function : Author
James R Cerhan
- Function : Author
Stephen J Chanock
- Function : Author
Jacqueline Clavel
- Function : Author
Lucia Conde
- Function : Author
Karen H Cotenbader
- Function : Author
David G Cox
- Function : Author
Wendy Cozen
- Function : Author
Simon Crouch
- Function : Author
Anneclaire J De Roos
- Function : Author
Silvia De Sanjose
- Function : Author
Simonetta Di Lollo
- Function : Author
W Ryan Diver
- Function : Author
Ahmet Dogan
- Function : Author
Lenka Foretova
- Function : Author
Hervé Ghesquières
- Function : Author
- PersonId : 758237
- IdRef : 067203779
Graham G Giles
- Function : Author
Bengt Glimelius
- Function : Author
Thomas M Habermann
- Function : Author
Corinne Haioun
- Function : Author
Patricia Hartge
- Function : Author
Henrik Hjalgrim
- Function : Author
Theodore R Holford
- Function : Author
Elizabeth A Holly
- Function : Author
Rebecca D Jackson
- Function : Author
Rudolph Kaaks
- Function : Author
Eleanor Kane
- Function : Author
Rachel S Kelly
- Function : Author
Robert J Klein
- Function : Author
Peter Kraft
- Function : Author
- PersonId : 765918
- ORCID : 0000-0002-4472-8103
Anne Kricker
- Function : Author
Qing Lan
- Function : Author
Charles Lawrence
- Function : Author
Mark Liebow
- Function : Author
Tracy Lightfoot
- Function : Author
Brian K Link
- Function : Author
James Mckay
- Function : Author
Mads Melbye
- Function : Author
Thierry J Molina
- Function : Author
Alain Monnereau
- Function : Author
Lindsay M Morton
- Function : Author
Alexandra Nieters
- Function : Author
Kari E North
- Function : Author
Anne J Novak
- Function : Author
Kenneth Offit
- Function : Author
Mark P Purdue
- Function : Author
Marco Rais
- Function : Author
Jacques Riby
- Function : Author
Eve Roman
- Function : Author
Nathaniel Rothman
- Function : Author
Gilles Salles
- Function : Author
- PersonId : 765692
- ORCID : 0000-0002-9541-8666
- IdRef : 067204236
Gianluca Severi
- Function : Author
- PersonId : 775780
- IdHAL : gianluca-severi
- ORCID : 0000-0001-7157-419X
- IdRef : 198040598
Richard K Severson
- Function : Author
Christine F Skibola
- Function : Author
Susan L Slager
- Function : Author
Alex Smith
- Function : Author
Martyn T Smith
- Function : Author
Melissa C Southey
- Function : Author
Anthony Staines
- Function : Author
- PersonId : 779556
- ORCID : 0000-0001-9161-1357
Lauren R Teras
- Function : Author
Carrie A Thompson
- Function : Author
Hervé Tilly
- Function : Author
Lesley F Tinker
- Function : Author
Anne Tjonneland
- Function : Author
Jenny Turner
- Function : Author
Claire M Vajdic
- Function : Author
Roel C H Vermeulen
- Function : Author
Joseph Vijai
- Function : Author
- PersonId : 768762
- ORCID : 0000-0002-7933-151X
Paolo Vineis
- Function : Author
Jarmo Virtamo
- Function : Author
Zhaoming Wang
- Function : Author
Stephanie Weinstein
- Function : Author
Thomas E Witzig
- Function : Author
Andrew Zelenetz
- Function : Author
Anne Zeleniuch-Jacquotte
- Function : Author
Yawei Zhang
- Function : Author
Tongzhang Zheng
- Function : Author
Abstract
ObjectiveDeterminants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genome-wide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL.Methods GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis.ResultsAmong the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765.ConclusionsThese data suggest several plausible genetic links between DLBCL and SLE.
Origin | Publication funded by an institution |
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