Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma

Sasha Bernatsky (1) , Héctor a Velásquez García , John J Spinelli , Patrick Gaffney (2) , Karin E Smedby , Rosalind Ramsey-Goldman , Sophia S Wang , Hans-Olov Adami , Demetrius Albanes , Emanuele Angelucci , Stephen M Ansell , Yan W Asmann , Nikolaus Becker , Yolanda Benavente , Sonja I Berndt , Kimberly A Bertrand , Brenda M Birmann , Heiner Boeing , Paolo Boffetta , Paige M Bracci , Paul Brennan , Angela R Brooks-Wilson , James R Cerhan , Stephen J Chanock , Jacqueline Clavel , Lucia Conde , Karen H Cotenbader , David G Cox , Wendy Cozen , Simon Crouch , Anneclaire J De Roos , Silvia De Sanjose , Simonetta Di Lollo , W Ryan Diver , Ahmet Dogan , Lenka Foretova , Hervé Ghesquières , Graham G Giles , Bengt Glimelius , Thomas M Habermann , Corinne Haioun , Patricia Hartge , Henrik Hjalgrim , Theodore R Holford , Elizabeth A Holly , Rebecca D Jackson , Rudolph Kaaks , Eleanor Kane , Rachel S Kelly , Robert J Klein , Peter Kraft , Anne Kricker , Qing Lan , Charles Lawrence , Mark Liebow , Tracy Lightfoot , Brian K Link , Marc Maynadie (3, 4, 5, 6) , James Mckay , Mads Melbye , Thierry J Molina , Alain Monnereau , Lindsay M Morton , Alexandra Nieters , Kari E North , Anne J Novak , Kenneth Offit , Mark P Purdue , Marco Rais , Jacques Riby , Eve Roman , Nathaniel Rothman , Gilles Salles , Gianluca Severi , Richard K Severson , Christine F Skibola , Susan L Slager , Alex Smith , Martyn T Smith , Melissa C Southey , Anthony Staines , Lauren R Teras , Carrie A Thompson , Hervé Tilly , Lesley F Tinker , Anne Tjonneland , Jenny Turner , Claire M Vajdic , Roel C H Vermeulen , Joseph Vijai , Paolo Vineis , Jarmo Virtamo , Zhaoming Wang , Stephanie Weinstein , Thomas E Witzig , Andrew Zelenetz , Anne Zeleniuch-Jacquotte , Yawei Zhang , Tongzhang Zheng , Mariagrazia Zucca And (7) , Ann E Clarke (7)

1 MUHC - McGill University Health Center [Montreal]
2 Oklahoma Medical Research Foundation
3 Registre des hémopathies malignes de Côte d'Or
4 CEP - Centre d'épidémiologie des populations
5 UBFC - Université Bourgogne Franche-Comté [COMUE]
6 CHU Dijon
7 University of Calgary

ObjectiveDeterminants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genome-wide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL.Methods GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis.ResultsAmong the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765.ConclusionsThese data suggest several plausible genetic links between DLBCL and SLE.

Keywords: Systemic lupus; lymphoma; malignancy

Domains: Cancer

Sasha Bernatsky, Héctor a Velásquez García, John J Spinelli, Patrick Gaffney, Karin E Smedby, et al.. Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma. Lupus science & medicine, 2017, 4 (1), pp.e000187. ⟨10.1136/lupus-2016-000187⟩. ⟨hal-01726625⟩