Decreased tryptophan and increased kynurenine levels in mastocytosis associated with digestive symptoms. - Microorganismes, Molécules Bioactives et Physiopathologie Intestinale Access content directly
Journal Articles Allergy Year : 2016

Decreased tryptophan and increased kynurenine levels in mastocytosis associated with digestive symptoms.

Angèle Soria

Abstract

The main metabolism pathway of tryptophan is protein formation, but it can also be metabolized into serotonin and kynurenine. Indoleamine 2,3-dioxygenase (IDO) is the enzyme that catalyzes the degradation of tryptophan into kynurenine. Mastocytosis is a heterogeneous disease characterized by mast cell accumulation in various tissues with 57% of patients having gastrointestinal involvement. We studied tryptophan metabolism in mastocytosis patients displaying or not gastrointestinal features and healthy subjects (n = 26 in each group). Mastocytosis patients with digestive symptoms displayed significantly increased kynurenine level and IDO activity as compared to healthy controls and mastocytosis patients without digestive symptoms. This could be linked to mast cell-mediated digestive inflammation among patients with mastocytosis. This work is the first focusing on kynurenine pathway in a mast cell disease and could help to understand the pathogenesis of digestive features in mastocytosis as well as in other mast cell-mediated diseases.
Fichier principal
Vignette du fichier
Georgin-Lavialle_2016_Decreased.pdf (281.85 Ko) Télécharger le fichier
Origin Files produced by the author(s)
Loading...

Dates and versions

hal-01269697 , version 1 (23-03-2016)

Identifiers

Cite

Sophie Georgin-Lavialle, Jean-Marie Launay, Francine Côté, Erinn Soucié, Angèle Soria, et al.. Decreased tryptophan and increased kynurenine levels in mastocytosis associated with digestive symptoms.. Allergy, 2016, 71 (3), pp.416-420. ⟨10.1111/all.12802⟩. ⟨hal-01269697⟩
860 View
1679 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More