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Book Sections Year : 2016

Toxicological interactions between mycotoxins

Abstract

Humans and animals are exposed to several toxins at the same time. The toxicity of combinations of mycotoxins cannot always be predicted based upon their individual toxicities. Interactions between concomitantly occurring mycotoxins can be antagonistic, additive, or synergistic. Several approaches have been used to determine the interaction between mycotoxins. The theoretical biology-based models of additivity, especially the Chou-Talalaymethod, are the most advanced. Using this latter model in several cellular systems and in an ex vivo intestinal explants system, we have observed a synergistic toxicity for trichothecenes, especially at low concentrations. The synergistic effects observed after exposure to a mixture of low concentrations of mycotoxins could pose a significant threat to public health.
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Dates and versions

hal-01603645 , version 1 (07-06-2023)

Identifiers

  • HAL Id : hal-01603645 , version 1
  • PRODINRA : 396627

Cite

Imourana Alassane-Kpembi, Isabelle P. Oswald. Toxicological interactions between mycotoxins. Paula Alvito; Ricardo Assunçao; Henriqueta Louro; Maria Joao Silva; Elsa Vasco. Food contaminants and human health: Challenges in chemical mixtures, National Institute of Health Doutor Ricardo Jorge, 4 p., 2016, 978-989-8794-20-8. ⟨hal-01603645⟩
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