Role of biotransformation in the mutagenicity of Versicolorin A, a precursor of Aflatoxin B1 - Biosynthèse & Toxicité des Mycotoxines Access content directly
Conference Poster Year : 2023

Role of biotransformation in the mutagenicity of Versicolorin A, a precursor of Aflatoxin B1

Carine Al-Ayoubi
  • Function : Author
  • PersonId : 1095780
Elodie Person
Sandrine S. Bruel
Alyssa Bouville
  • Function : Author
  • PersonId : 1181804
Philippe Pinton
  • Function : Author
  • PersonId : 948088
Emilien Jamin
Olivier Puel
Ariane Vettorazzi

Abstract

Aflatoxin B1 (AFB1) exhibits the most severe toxicological effects of all known mycotoxins. Versicolorin A (VerA) is a precursor in the biosynthesis of AFB1. Both toxins are produced by the same aflatoxigenic species and can therefore co-contaminate food commodities. It is well established that the in vivo bioactivation of AFB1 into a highly reactive molecule is the key step in the mutagenic process. In contrast, much less is known about the toxicity of VerA and no information is available on its metabolization.
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Dates and versions

hal-04357518 , version 1 (21-12-2023)

Identifiers

  • HAL Id : hal-04357518 , version 1

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Carine Al-Ayoubi, Justin Oules, Elodie Person, Sandrine S. Bruel, Alyssa Bouville, et al.. Role of biotransformation in the mutagenicity of Versicolorin A, a precursor of Aflatoxin B1. Mycotoxins and Phycotoxins Gordon Research Conference, Jun 2023, Boston (MA), United States. ⟨hal-04357518⟩
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