Early hybrid cardiac rehabilitation in congenital heart disease: the QUALIREHAB trial
Pascal Amedro
,
Arthur Gavotto
(1, 2)
,
Helena Huguet
,
Luc Souilla
,
Anne-Cecile Huby
,
Stefan Matecki
(1, 2)
,
Anne Cadene
,
Gregoire de la Villeon
,
Marie Vincenti
(1, 2)
,
Oscar Werner
,
Charlene Bredy
,
Kathleen Lavastre
,
Hamouda Abassi
(1, 2)
,
Sarah Cohen
,
Sebastien Hascoet
(3)
,
Claire Dauphin
,
Aurelie Chalard
,
Yves Dulac
,
Nathalie Souletie
,
Helene Bouvaist
,
Stephanie Douchin
,
Matthias Lachaud
,
Caroline Ovaert
,
Camille Soulatges
,
Nicolas Combes
,
Jean-Benoit Thambo
,
Xavier Iriart
,
Fanny Bajolle
,
Damien Bonnet
,
Helene Ansquer
,
Jean-Guillaume Delpey
,
Laurence Cohen
,
Marie-Christine Picot
(4)
,
Sophie Guillaumont
,
Pascal Amedro
,
Arthur Gavotto
,
Helena Huguet
,
Luc Souilla
,
Anne-Cecile Huby
,
Johanna Calderon
,
Stefan Matecki
,
Anne Cadene
,
Gregoire de la Villeon
,
Marie Vincenti
,
Oscar Werner
,
D’arcy Vandenberghe
,
Charlene Bredy
,
Kathleen Lavastre
,
Hamouda Abassi
,
Sarah Cohen
,
Sebastien Hascoet
(3)
,
Claire Dauphin
,
Aurelie Chalard
,
Yves Dulac
,
Nathalie Souletie
,
Philippe Acar
,
Helene Bouvaist
,
Stephanie Douchin
,
Matthias Lachaud
,
Caroline Ovaert
,
Camille Soulatges
,
Nicolas Combes
,
Jean-Benoit Thambo
,
Xavier Iriart
,
Emilie Testet
,
Fanny Bajolle
,
Antoine Legendre
,
Damien Bonnet
,
Helene Ansquer
,
Jean-Guillaume Delpey
,
Laurence Cohen
,
Victor Pommier
,
Remi Vincent
,
Frederique Sidney-Hetmaniak
,
Laurent Poirette
,
Sonia Corone
,
Cecile Rocca
,
Marianne Noirclerc
,
Oxana-Anca Neagu
,
Hervé Ngayap-Nemkam
,
Isaam Kammache
,
Clara Bourgarde
,
Jean-Marie Chevalier
,
Christelle Pons
,
Marie-Christine Picot
(4)
,
Sophie Guillaumont
Pascal Amedro
- Function : Author
- PersonId : 781422
- ORCID : 0000-0003-3649-0294
- IdRef : 091010861
Arthur Gavotto
- Function : Author
- PersonId : 1183310
- ORCID : 0000-0001-6485-7634
Helena Huguet
- Function : Author
Anne-Cecile Huby
- Function : Author
Stefan Matecki
- Function : Author
- PersonId : 20443
- IdHAL : stefan-matecki
- ORCID : 0000-0002-1878-0936
- IdRef : 066832357
Anne Cadene
- Function : Author
Gregoire de la Villeon
- Function : Author
Oscar Werner
- Function : Author
- PersonId : 1359206
- ORCID : 0000-0002-3741-0498
Charlene Bredy
- Function : Author
Kathleen Lavastre
- Function : Author
Sarah Cohen
- Function : Author
Sebastien Hascoet
- Function : Author
- PersonId : 736026
- IdHAL : sebastien-hascoet
- ORCID : 0000-0002-8695-0503
- IdRef : 164937978
Claire Dauphin
- Function : Author
Aurelie Chalard
- Function : Author
Yves Dulac
- Function : Author
- PersonId : 1359207
- ORCID : 0000-0002-7027-6358
Nathalie Souletie
- Function : Author
Helene Bouvaist
- Function : Author
- PersonId : 1359208
- ORCID : 0000-0002-8243-3971
Stephanie Douchin
- Function : Author
- PersonId : 1359209
- ORCID : 0000-0002-6437-4648
Matthias Lachaud
- Function : Author
- PersonId : 1359210
- ORCID : 0000-0001-8406-3399
Caroline Ovaert
- Function : Author
- PersonId : 786621
- ORCID : 0000-0002-2277-2760
Camille Soulatges
- Function : Author
Nicolas Combes
- Function : Author
- PersonId : 770183
- ORCID : 0000-0002-5238-7791
Jean-Benoit Thambo
- Function : Author
- PersonId : 1359211
- ORCID : 0000-0001-5738-965X
Xavier Iriart
- Function : Author
- PersonId : 1344894
- ORCID : 0000-0002-4911-7432
Fanny Bajolle
- Function : Author
- PersonId : 1252155
- ORCID : 0000-0002-1106-0987
Damien Bonnet
- Function : Author
- PersonId : 757220
- ORCID : 0000-0002-8722-5805
- IdRef : 067147569
Helene Ansquer
- Function : Author
Jean-Guillaume Delpey
- Function : Author
Laurence Cohen
- Function : Author
Marie-Christine Picot
- Function : Author
- PersonId : 862745
- IdHAL : marie-christine-picot
- ORCID : 0000-0003-4204-7299
Sophie Guillaumont
- Function : Author
- PersonId : 1262118
- ORCID : 0000-0002-7960-4776
Pascal Amedro
- Function : Author
Arthur Gavotto
- Function : Author
Helena Huguet
- Function : Author
Luc Souilla
- Function : Author
Anne-Cecile Huby
- Function : Author
Johanna Calderon
- Function : Author
Stefan Matecki
- Function : Author
Anne Cadene
- Function : Author
Gregoire de la Villeon
- Function : Author
Marie Vincenti
- Function : Author
Oscar Werner
- Function : Author
D’arcy Vandenberghe
- Function : Author
Charlene Bredy
- Function : Author
Kathleen Lavastre
- Function : Author
Hamouda Abassi
- Function : Author
Sarah Cohen
- Function : Author
Claire Dauphin
- Function : Author
Aurelie Chalard
- Function : Author
Yves Dulac
- Function : Author
Nathalie Souletie
- Function : Author
Philippe Acar
- Function : Author
Helene Bouvaist
- Function : Author
Stephanie Douchin
- Function : Author
Matthias Lachaud
- Function : Author
Caroline Ovaert
- Function : Author
Camille Soulatges
- Function : Author
Nicolas Combes
- Function : Author
Jean-Benoit Thambo
- Function : Author
Xavier Iriart
- Function : Author
Emilie Testet
- Function : Author
Fanny Bajolle
- Function : Author
Antoine Legendre
- Function : Author
Damien Bonnet
- Function : Author
Helene Ansquer
- Function : Author
Jean-Guillaume Delpey
- Function : Author
Laurence Cohen
- Function : Author
Victor Pommier
- Function : Author
Remi Vincent
- Function : Author
Frederique Sidney-Hetmaniak
- Function : Author
Laurent Poirette
- Function : Author
Sonia Corone
- Function : Author
Cecile Rocca
- Function : Author
Marianne Noirclerc
- Function : Author
Oxana-Anca Neagu
- Function : Author
Hervé Ngayap-Nemkam
- Function : Author
Isaam Kammache
- Function : Author
Clara Bourgarde
- Function : Author
Jean-Marie Chevalier
- Function : Author
Christelle Pons
- Function : Author
Sophie Guillaumont
- Function : Author
Abstract
Abstract Background and Aims Cardiopulmonary fitness in congenital heart disease (CHD) decreases faster than in the general population resulting in impaired health-related quality of life (HRQoL). As the standard of care seems insufficient to encourage and maintain fitness, an early hybrid cardiac rehabilitation programme could improve HRQoL in CHD. Methods The QUALIREHAB multicentre, randomized, controlled trial evaluated and implemented a 12-week centre- and home-based hybrid cardiac rehabilitation programme, including multidisciplinary care and physical activity sessions. Adolescent and young adult CHD patients with impaired cardiopulmonary fitness were randomly assigned to either the intervention (i.e. cardiac rehabilitation) or the standard of care. The primary outcome was the change in HRQoL from baseline to 12-month follow-up in an intention-to-treat analysis. The secondary outcomes were the change in cardiovascular parameters, cardiopulmonary fitness, and mental health. Results The expected number of 142 patients was enroled in the study (mean age 17.4 ± 3.4 years, 52% female). Patients assigned to the intervention had a significant positive change in HRQoL total score [mean difference 3.8; 95% confidence interval (CI) 0.2; 7.3; P = .038; effect size 0.34], body mass index [mean difference −0.7 kg/m2 (95% CI −1.3; −0.1); P = .022; effect size 0.41], level of physical activity [mean difference 2.5 (95% CI 0.1; 5); P = .044; effect size 0.39], and disease knowledge [mean difference 2.7 (95% CI 0.8; 4.6); P = .007; effect size 0.51]. The per-protocol analysis confirmed these results with a higher magnitude of differences. Acceptability, safety, and short-time effect of the intervention were good to excellent. Conclusions This early hybrid cardiac rehabilitation programme improved HRQoL, body mass index, physical activity, and disease knowledge, in youth with CHD, opening up the possibility for the QUALIREHAB programme to be rolled out to the adult population of CHD and non-congenital cardiac disease.
Domains
Life Sciences [q-bio]
Origin : Files produced by the author(s)